MORGAM logo

GER-AUG: Augsburg

Contributors from the MPC: Angela Döring, Christa Meisinger, Margit Heier, Barbara Thorand and Andrea Schneider


Valid HTML 4.01!
© National Institute for Health and Welfare and the MORGAM Project investigators
Last updated: 30 October 2013
For more information, please contact Kari Kuulasmaa (firstname.lastname@thl.fi)

Contents


Cohort identification

Cohort recruitment and the baseline examination

The cohorts were formed by the respondents of representative sample surveys of the RUs. List of municipalities and population registries were used as sampling frames for the first and the second stage of two-stage sampling, respectively. The second stage of the sampling was stratified by sex and 10-year age group. The baseline examinations of Cohorts 01-03 were carried out as part of the WHO MONICA Project, where they were recognized by codes GER-AURa (RU 02) and GER-AUUa (RU 01). RU 03 of MORGAM combines RUs 01 and 02 of MONICA. Similar methods were used for the baseline examination of Cohort 24 which was conducted in the frame of the Cooperative Research in the study Region of Augsburg (KORA). Follow-up studies were also conducted in the frame of KORA [6].

The size of the MORGAM cohorts and the response rates of the population surveys from which the cohorts were derived are:

RUA Cohort Round Men Women Total Response rate
GER-AUGa 01 01 2004 1976 3980 79%
02 01 2341 2298 4639 76%
03 01 2269 2211 4480 74%
24 01 2040 2125 4165 67%
02 1455 1564 3019  
Total 8654 8610 17264  

DNA is available for about 80% of all four cohorts.

End-points followed up:

End of follow-up period:

Follow-up procedures

Sources of data

Procedures

Within the framework of the KORA Studies, follow-up questionnaires were sent to each former participant in 1997-1998 [3], in 2002-2003 and in 2008-2009 to obtain information on the occurrence of chronic diseases and risk factors.

Mortality follow-up: If a person did not return the follow-up questionnaire, the person's vital status was ascertained through the population registries inside and outside the study area. Record linkage was based on name, sex, date of birth and address. If the person died, the information on when and where is provided by the population registries and a copy of the death certificate is obtained from the Regional Health Department. If the person moved out of the study area, the time of move and usually the information on the new address is available. The vital status could not be assessed for those who had moved to a foreign country or to an unknown location in the country.

Follow-up of CHD events: Each time a non-fatal event was reported to the Coronary Events Registry, it was linked to the cohorts using name and date of birth. All deaths in the cohorts were linked to the Coronary Events Registry using the dates of birth and death. If a person has moved out of the study area, information from the follow-up questionnaire was used and general practitioner's notes and hospital discharge letters were gathered. If such a person did not return the questionnaire, the date of moving outside the study area is known through the population registries and the date of loss to follow-up for non-fatal events was the date of moving. Non-fatal events were not followed up for those who had a self-reported MI at baseline.

Follow-up of STROKE events: The end points used in this study were incidence of fatal or nonfatal stroke. Transient ischemic attack was not included. All incident cases of stroke (subarachnoid haemorrhage, intracerebral haemorrhage, cerebral infarction) which had been diagnosed up to 2009 were included. Self-reported incident cases of stroke and the date of diagnosis were validated by hospital records or by contacting the treating physician. Furthermore, the hospital records of those deceased during the follow-up period without a diagnosis of stroke at baseline were also examined and/or their last treating physicians were contacted. The records were searched, or the physicians were asked for a history of stroke and if a person had suffered from stroke, the type of stroke and the date of diagnosis but not the ICD-code of the clinical diagnosis were ascertained. 3% of the self-reported strokes could not be validated. These were censored at a date prior to the self-reported date of stroke. If this was not possible we used the date of examination for censoring.

Follow-up of DIABETES: The end point used in this study was incidence of diabetes (type 1, type 2 and other types). All incident cases of diabetes which had been diagnosed up to 2009 were included. Self-reported incident cases of diabetes and the date of diagnosis were validated by hospital records or by contacting the treating physician. Furthermore, the hospital records of those deceased during the follow-up period without a diagnosis of diabetes at baseline were also examined and/or their last treating physician was contacted. The records were searched, or the physicians were asked for a history of diabetes and if a person had suffered from diabetes the type of diabetes and the date of diagnosis were ascertained.

Diagnostic procedures

At baseline:

During follow-up:

References

  1. Löwel H, Lewis M, Hörmann A, Keil U. Case finding, data quality aspects and comparability of myocardial infarction registers: Results of a south German register study. J Clin Epidemiol. 1991;44(3):249-260.
  2. Keil U, Liese AD, Hense HW, Filipiak B, Doring A, Stieber J, Lowel H. Classical risk factors and their impact on incident non-fatal and fatal myocardial infarction and all-cause mortality in southern Germany. Results from the MONICA Augsburg cohort study 1984-1992. Monitoring Trends and Determinants in Cardiovascular Diseases. Eur Heart J. 1998;19(8):1197-207.
  3. Meisinger C, Thorand B, Schneider A, Stieber J, Doering A, Loewel H. Sex differences in risk factors for incident type 2 diabetes mellitus. The MONICA Augsburg Cohort Study. Arch Intern Med 2002; 162:82–9.
  4. Löwel H, Döring A, Schneider A, Heier M, Thorand B, Meisiger C, for the MONICA/KORA Study Group. The MONICA Augsburg Surveys – Basis for Prospective Cohort Studies. Gesundheitswesen 2005; 67: S13-S18.
  5. Löwel H, Meisinger C, Heier M, Hörmann A. The Population-Based Acute Myocardial Infarction (AMI) Registry of the MONICA/KORA-Study Region of Augsburg. Gesundheitswesen 2005; 67: S31-S37.
  6. Holle R, Happich M, Löwel H, Wichmann HE, for the MONICA/KORA Study Group. KORA – A Research Platform for Population Based Health Research. Gesundheitswesen 2005; 67: S19-25.
     

Updates to this document

Date Update
2006-05-14 Date of the first published version.
2008-01-18 The name of the Administrative centre and the list of Key personnel was updated.
2010-05-19 The baseline age range of Cohorts 02 and 03 was extended from 64 years to 74 years, and the cohort description was updated accordingly.
2013-09-21 Follow-up period was extended, Cohort 24 was added, and follow-up of non-fatal strokes was added to Cohorts 03, 24, 33 and 34.

previous next contents