|
This page last changed on 19.01.2015 by ttuv.
Link to Northern Sweden - other cohorts and data sources
Contact person(s) for the cohort description
Ulrika Pettersson
Partner
Institute
Department of Clinical Pharmacology, Umeå University.
Key personnel for CHANCES
Responsible person: Ulrika Pettersson
Other Key personnel: Sture Eriksson
Definition of the cohort
Target population
All age groups, (except children), with bone density data.
Recruitment
This cohort is based on the same population as the other Umeå based cohorts. These cohorts are mainly through referral for bone density measurement but also other cohorts.
Years of recruitment
Ongoing
Size of the cohort
Depending on type of data.
Measurements at baseline and recontacts
Clinical measurement, Bone density, Serum markers, Genetic data, Dietary data, Life style data, Diseases.
| Socioeconomic |
Baseline |
| Education |
Yes |
| Income |
Can be added |
| Marital status |
Yes |
| Occupation |
No |
| Employment status |
No |
| History of |
Baseline |
| Diabetes |
Yes |
| Dyslipidemia |
No |
| Coronary heart disease |
Yes |
| Stroke |
Yes |
| Cancer |
Yes |
| Benign neoplasms |
No |
| Fracture |
Yes |
| - Which site(s)? |
Hip and wrist and low trauma fractures X-ray verified and ICD codes. Hip, waist and low-trauma fractures > 50 yrs of age. |
| Osteoporosis |
Yes, with Lunar DEXA. Total body, Lumar spine, Femoral neck, total hip BMS. Also lean and fat mass. |
| Family history of |
Baseline |
| Coronary heart disease |
No |
| Stroke |
Yes |
| Diabetes |
Yes |
| Cancer |
No |
| Lifestyle |
Baseline |
| Current smoking |
Yes |
| Past smoking |
Yes |
| Alcohol use |
Yes |
| Physical activity |
Yes, past, present, training, commuting, occupational and childhood activities |
| Nutrition (yes/no) |
No |
| - Number of food items available (approximately) |
|
| - Method(s) of dietary assessment (e.g. 24h-recall, food frequency questionnaire, dietary records) |
|
| - Supplement use |
|
| Anthropometry |
Baseline |
| Weight and height |
Yes |
| - Measured or self-reported |
Measured |
| Unintended weight loss |
No |
| Waist circumference |
No |
| - Measured or self-reported |
|
| Hip circumference |
No |
| Measured or self-reported |
|
| Blood pressure |
Baseline |
| Measured blood pressure |
Yes |
| History of hypertension |
Yes |
| Blood tests |
Baseline |
| Total cholesterol |
Yes |
| HDL cholesterol |
Yes |
| Triglycerides |
Yes |
| - Fasting period |
|
| ApoA1 |
No |
| ApoB |
No |
| Glucose |
Yes, including 2 h bglc |
| - Fasting period |
|
| Glucose tolerance test |
Yes |
| HbA1c |
No |
| GGT |
No |
| CRP |
No |
| 25-Hydroxy-Vitamin D |
Yes (25 OH, 25 OH D3, total vit D.) |
| Other tests (specify) |
Retinol, Terinylesteras, PTH, Fatty acids, Osteocalcin, CTx |
| Availability of frozen sera for further analysis |
No |
| - Storage temperature (°C) of sera |
|
| Availability of frozen plasma for further analysis |
Yes |
| - Storage temperature (°C) of plasma |
-80 |
| Genetics |
Baseline |
| Genotypic data |
|
| GWAS (specify) |
|
| Other high-throughput array data (specify) |
WGA 1100 hip cases + 1400 controls |
| Availability of DNA for further genotyping |
No |
| Plated DNA |
|
| Otherwise stored DNA |
|
| Other measurements |
Baseline |
| Perceived health |
No |
| Cognitive decline/dementia |
No |
| Depression |
No |
| Grip Strength |
No |
| Lung function |
No |
| Audiometry |
No |
| Measurement of bone density (DEXA) |
Yes |
| Quality of life instruments (such as SF-12, EUROQoL) |
No |
| Limitations in ADL/IADL (i.e. Activities of daily living/Instrumental activities of daily living) |
No |
| Multimorbidity instruments (such as CIRS-G) |
No |
| Frailty scales |
No |
| Reproductive history (for women) |
No |
| Menstruation and menopausal status |
|
| Fertility problems |
|
| Pregnancies |
|
| Breast feeding |
|
| Hysterectomy and ovariectomy |
|
| History of oral contraceptive use |
|
| History of menopausal hormones use |
|
| Current use of exogenous hormones |
|
| Use of drugs |
Yes |
| Availability of classification of drugs, specify (e.g. Anatomical Therapeutic Chemical(ATC) classification system) |
ATC codes |
| Additional Topics |
Baseline |
| |
Dietary data such as total energy, fat, protein, betacarotene, Iron, Ca, Vit B2, B12, folic acid, Phytoestrogene, selen, fibres, sackaros, fatty acids (C16, C18, C20, C22) |
Follow-up
Follow-up period
Ongoing
Sources of data
Medical records and various registries
Follow-up procedure
Record linkage with registries
End-points covered through the follow-up
- All deaths: yes
- Specification of the cause:
- Non-fatal acute coronary events: yes
- Cognitive impairment/dementia: No
- Nursing home admission: No
ICD-version used for classification of diseases in the data
References
|
