CHANCES : The Epic Elderly and Northern Sweden Epic Study-UMEA
This page last changed on 30.01.2015 by x_ljaq.

Link to EPIC Elderly cohort description

Contact person(s) for the cohort description

Gerd Johansson

Partner

Institute

UMU - Umea Universitet

Key personnel for CHANCES

Responsible person: Sture Eriksson

Other Key personnel: Göran Hallmans, PI, The Northern Sweden EPIC Study. Olov Rolandsson is contact person when it comes to diabetes and Patrik Wennberg and Jan-Hakan Jansson for CVD, Ulrika Petterson Kymmer for osteoporosis.

Definition of the cohort

Target population

The Northern Sweden Epic Study: The cohort consists of individuals 30, 40, 50 and 60 years of age, both men and women. The Northern Sweden Epic Study is a part of the Northern Sweden Health and Disease Study (NSHDS), ongoing from 1985.

The Epic Elderly Study: The cohort consists of the older individuals of the Northern Sweden EPIC cohort from 60 and above. The Epic elderly is a subset of the Northern Sweden Epic study. Se descriptions below.

Recruitment

Volunteers from a target population that covers the whole province of Västerbotten (North of Sweden).

Years of recruitment

1992-1996

Size of the cohort

The Northern Sweden Epic Study: 25 725 individuals.

The Epic Elderly Study: 3 364 subjects

Recontacts

Period

The Northern Sweden Epic Study: Every 10th years

The Epic Elderly Study: Recontact is on a planning stage (Northpop project)

Approach

The Northern Sweden Epic Study: "Invitation to a re-examination", 2002-2006. Data collection accomplished by means of questionnaires combined with an interview. The response rate is approx. 60%.

The Epic Elderly Study: Examination and data collection as above  combined with matching genealogical data (from church records). Web-based questionnaires will focus on estimating changes over time in lifestyle factors such as physical activity, emotional stress, socio-economical conditions and diet, which all are expected to influence progression of Neurodegenerative diseases, Osteoarthritis, Cardiovascular disease and some cancers. There will also be specific genealogical questions concerning occurrence of obesity and fractures and different tests of Cognitive impairment.

Measurements at the baseline are the same in the cohorts. Recontact 1 is only for The Northern Sweden Epic Study. Recontacts are in a planning stage for The Epic Elderly Study

Measurements at baseline and recontacts

Socioeconomic Baseline Recontact 1
Education Yes Yes
Income No No
Marital status Yes Yes
Occupation Yes Yes
Employment status Yes Yes
History of Baseline Recontact 1
Diabetes Yes Yes
Dyslipidemia Yes Yes
Coronary heart disease Yes
Yes
Stroke Yes yes
Cancer Yes, partly
Yes, partly
Benign neoplasms ? ?
Fracture Yes, partly
Yes, partly
  - Which site(s)? Wrist and hip
Wrist and hip
Osteoporosis Yes, partly
Yes, partly
Family history of Baseline Recontact 1
Coronary heart disease Yes Yes
Stroke Yes Yes
Diabetes Yes Yes
Cancer Yes, partly Yes, partly
Lifestyle Baseline Recontact 1
Current smoking Yes Yes
Past smoking Yes Yes
Alcohol use Yes Yes
Physical activity Yes Yes
Nutrition (yes/no) Yes Yes
  - Number of food items available (approximately) 84
64
  - Method(s) of dietary assessment (e.g. 24h-recall, food frequency questionnaire, dietary records) Semi-quantitative food frequency questionnaire on the whole study population and a 24 h-recall in a random sub-sample of the study population
Semi-quantitative food frequency questionnaire
  - Supplement use Yes
Yes
Anthropometry Baseline Recontact 1
Weight and height Yes
Yes
  - Measured or self-reported Measured
Measured
Unintended weight loss No No
Waist circumference Yes, partly Yes, partly
  - Measured or self-reported Measured
Measured
Hip circumference Yes, partly Yes, partly
Measured or self-reported Measured Measured
Blood pressure Baseline Recontact 1
Measured blood pressure Yes
Yes
History of hypertension Yes Yes
Blood tests Baseline Recontact 1
Total cholesterol Yes Yes
HDL cholesterol Yes Yes
Triglycerides Yes Yes
  - Fasting period Yes Yes
ApoA1 No No
ApoB No No
Glucose Yes Yes
  - Fasting period Yes
Yes
Glucose tolerance test Yes Yes
HbA1c No
No
GGT No
No
CRP Yes, partly
Yes, partly
25-Hydroxy-Vitamin D No No
Other tests (specify) No
No
Availability of frozen sera for further analysis No No
  - Storage temperature (°C) of sera
   
Availability of frozen plasma for further analysis Yes Yes
  - Storage temperature (°C) of plasma
-80°
-80°
Genetics Baseline Recontact 1
Genotypic data Yes, partly Yes, partly
GWAS (specify) Yes, partly Yes, partly
Other high-throughput array data (specify) No
No
Availability of DNA for further genotyping Yes
Yes
Plated DNA Yes, partly Yes, partly
Otherwise stored DNA Buffy coat
Buffy coat
Other measurements Baseline Recontact 1
Perceived health Yes
Yes
Cognitive decline/dementia Yes, partly
Yes, partly
Depression No
No
Grip Strength No
No
Lung function No
No
Audiometry No No
Measurement of bone density (DEXA) No No
Quality of life instruments (such as SF-12, EUROQoL) No
No
Limitations in ADL/IADL (i.e. Activities of daily living/Instrumental activities of daily living) No No
Multimorbidity instruments (such as CIRS-G) No
No
Frailty scales No No
Reproductive history (for women) Yes, partly
Yes, partly
Menstruation and menopausal status Yes, partly Yes, partly
Fertility problems No No
Pregnancies Yes, partly Yes, partly
Breast feeding No
No
Hysterectomy and ovariectomy Yes, partly Yes, partly
History of oral contraceptive use Yes, partly Yes, partly
History of menopausal hormones use Yes, partly Yes, partly
Current use of exogenous hormones Yes, partly Yes, partly
Use of drugs Yes
Yes
Availability of classification of drugs, specify (e.g. Anatomical Therapeutic Chemical(ATC) classification system) Yes, ATC code
Yes, ATC code
Additional Topics Baseline Recontact 1
Living conditions
Yes
Yes
Social network
Yes
Yes

Future recontacts

The Northern Sweden Epic Study:  Follow-up of study participants are on-going at regular intervals (every 10 years) from the year of 1992.

The Epic Elderly Study: Recontacts is in a planning stage (Northpop 70).

Other follow-up

Follow-up is ongoing using record linkage with registry data on all major disease areas. Reported diagnoses of interest are further ascertained and information is supplemented by the use of specific registries and the use of medical records in hospitals and clinics whenever needed to get additional clinical information.

Follow-up period

Every 10 years from the baseline examination.

Sources of data

Death certificates obtained from regional and national health and death registries

Regional computerized hospital discharge register

Medical records of patients

Data from re-examination

Re-contact questionnaire.

Follow-up procedure

Record linkage to the national Causes of Death Register, using the unique personal identification number.

End-points covered through the follow-up

  • All deaths:
    • Specification of the cause: Yes
  • Non-fatal cancers: Yes
    • Cancer survival: Yes
  • Non-fatal acute coronary events: Yes
  • Non-fatal stroke: Yes
  • Non-fatal diabetes: Yes
  • Fractures: Yes
  • Cognitive impairment/dementia:Yes
  • Nursing home admission: No

ICD-version used for classification of diseases in the data

  • ICD-10 for causes of death and ICD-O-2 for classification of non-fatal cancers.

References

Reference to The Northern Sweden Health and Disease cohort (including The Northern Sweden Epic Study )

Hallmans G, Agren A, Johansson G, Johansson A, Stegmayr B, Jansson JH, Lindahl B, Rolandsson O, Soderberg S, Nilsson M, Johansson I Weinehall L. Cardiovascular disease and diabetes in the Northern Sweden Health and Disease Study Cohort – evaluation of risk factors and their interactions. Scand J Public Health 2003; 31(Suppl. 61): 18--24.
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