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This page last changed on 02.02.2015 by kkuk.
Link to Northern Sweden - other cohorts and data sources
Contact person(s) for the cohort description
Sture Eriksson
Partner
Institute
Sect of Psychogeriatrics, Dept of Rehabilitation and Community Medicine, Umeå University
Key personnel for CHANCES
Responsible person: Sture Eriksson
Other Key personnel: Lena Jacobsson
Description of the registry
This registry intends to collect persons with established dementia diagnosis, primarily Alzheimer Disease and have donated samples to the NSHDS before onset of dementia disorder.
Lists are produced of all patients with clinical dementia diagnosis in 1985 to 2009. These are matched with Medical Biobank registry to find those exsisting in both registries. Their medical records are reviewed to both gather data and verify that the clinical diagnosis is according to relevant guidelines.
Control patients will be recruited through the NSHDS. Those having AD or other dementia disorders do not qualify as controls.
Years of recruitment
1985-2009
Size of the cohort
422 verified AD patients. Finalized September 2012.
Measurements at baseline and recontacts
| Socioeconomic |
Baseline |
| Education |
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| Income |
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| Marital status |
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| Occupation |
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| Employment status |
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| History of |
Baseline |
| Diabetes |
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| Dyslipidemia |
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| Coronary heart disease |
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| Stroke |
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| Cancer |
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| Benign neoplasms |
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| Fracture |
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| - Which site(s)? |
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| Osteoporosis |
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| Family history of |
Baseline |
| Coronary heart disease |
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| Stroke |
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| Diabetes |
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| Cancer |
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| Lifestyle |
Baseline |
| Current smoking |
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| Past smoking |
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| Alcohol use |
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| Physical activity |
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| Nutrition (yes/no) |
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| - Number of food items available (approximately) |
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| - Method(s) of dietary assessment (e.g. 24h-recall, food frequency questionnaire, dietary records) |
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| - Supplement use |
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| Anthropometry |
Baseline |
| Weight and height |
Yes |
| - Measured or self-reported |
Measured |
| Unintended weight loss |
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| Waist circumference |
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| - Measured or self-reported |
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| Hip circumference |
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| Measured or self-reported |
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| Blood pressure |
Baseline |
| Measured blood pressure |
Yes |
| History of hypertension |
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| Blood tests |
Baseline |
| Total cholesterol |
No |
| HDL cholesterol |
No |
| Triglycerides |
No |
| - Fasting period |
No |
| ApoA1 |
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| ApoB |
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| Glucose |
Yes |
| - Fasting period |
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| Glucose tolerance test |
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| HbA1c |
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| GGT |
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| CRP |
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| 25-Hydroxy-Vitamin D |
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| Other tests (specify) |
Laboratory data at onset of disorder: SR, CRP, Hb, EPK, EVF, MCV, LPK, TPK, B12, Homocysteine, FOLAT, ALP, GT, ASAT, ALAT, GLC, TSH, T3, T4, NA, K , ALB, KREA, Ca tot, Ca corr |
| Availability of frozen sera for further analysis |
Yes, in MBB Umeå |
| - Storage temperature (°C) of sera |
-80 |
| Availability of frozen plasma for further analysis |
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| - Storage temperature (°C) of plasma |
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| Genetics |
Baseline |
| Genotypic data |
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| GWAS (specify) |
No |
| Other high-throughput array data (specify) |
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| Availability of DNA for further genotyping |
Yes |
| Plated DNA |
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| Otherwise stored DNA |
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| Other measurements |
Baseline |
| Perceived health |
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| Cognitive decline/dementia |
Yes, detailed information |
| Depression |
No |
| Grip Strength |
No |
| Lung function |
No |
| Audiometry |
No |
| Measurement of bone density (DEXA) |
No |
| Quality of life instruments (such as SF-12, EUROQoL) |
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| Limitations in ADL/IADL (i.e. Activities of daily living/Instrumental activities of daily living) |
Yes, AMPS (not complete) |
| Multimorbidity instruments (such as CIRS-G) |
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| Frailty scales |
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| Reproductive history (for women) |
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| Menstruation and menopausal status |
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| Fertility problems |
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| Pregnancies |
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| Breast feeding |
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| Hysterectomy and ovariectomy |
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| History of oral contraceptive use |
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| History of menopausal hormones use |
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| Current use of exogenous hormones |
Yes |
| Use of drugs |
Yes |
| Availability of classification of drugs, specify (e.g. Anatomical Therapeutic Chemical(ATC) classification system) |
Yes |
| Additional Topics |
Baseline |
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Body measurements: BMI, SBP, DBP, |
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Cognitive assessement: MMSE, Behave AD, FAST, AMPS, neuropsyhological assessement, |
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Imaging: CT, MR, SPECt (when accessible) |
Recontacts
Recontact within this cohort is not planned, but can be done for example with death registries.
Clinical registries, check information from medical records, validated diagnosis in relation to DSM IV.
Other follow-up
Sources of data
NSHDS and clinical medical records and data from other can be added for example via ALC.
End-points covered through the follow-up
- Non-fatal acute coronary events: No
- Cognitive impairment/dementia: Yes
- Nursing home admission: Yes
ICD-version used for classification of diseases in the data:
References
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