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This page last changed on 05.02.2015 by ttuv.
Link to MORGAM cohort description
PRIME Belfast participates in the MORGAM Project, and the PRIME Belfast data which have been harmonized to the MORGAM database is specified in the cohort description of MORGAM (as RUA UNK-BEL). This page describes the parts of PRIME Belfast which are not included in MORGAM but may be relevant to CHANCES.
Contact person(s) for this cohort description
Mark O'Doherty
Institute
The Queen's University of Belfast, Belfast, Northern Ireland
Key personnel for CHANCES
Principal Investigator - Prof Frank Kee (f.kee@qub.ac.uk)
Former Principal Investigator: Alun Evans
Definition of the cohort
see MORGAM
Target population
see MORGAM
Recruitment
see MORGAM
Years of recruitment
see MORGAM
Size of the cohort
see MORGAM
Recontacts
Recontact 1 -
~10 year follow-up re-examination performed
Period
2001-2006
Approach
similar to baseline (questionnaires and blood samples)
- 2010 participants in this round
- follow-up of endpoints extended to ~18 years
Measurements at baseline and recontacts
see MORGAM for baseline measurements that have been harmonized to the MORGAM database from PRIME Belfast.
Below are measurements that have not been harmonized to the MORGAM database, but are available within PRIME Belfast and may be relevant to CHANCES (the recontact data and updated follow-up is currently being harmonized to the MORGAM database and will be reported by MORGAM soon).
| Socioeconomic |
Baseline |
Recontact1 |
| Education |
|
No |
| Income |
|
No |
| Marital status |
|
Yes |
| Occupation |
|
No |
| Employment status |
|
No |
| History of |
Baseline |
Recontact1 |
| Diabetes |
|
Yes |
| High cholesterol |
|
Yes |
| Coronary heart disease |
|
Yes |
| Stroke |
|
Yes |
| Cancer |
|
No |
| Benign neoplasms |
|
No |
| Fracture |
|
No |
| - Which site(s)? |
|
|
| Osteoporosis |
|
No |
| Family history of |
Baseline |
Recontact1 |
| Coronary heart disease |
|
No |
| Stroke |
|
No |
| Diabetes |
|
No |
| Cancer |
|
No |
| Hypertension |
|
No |
| Lifestyle |
Baseline |
Recontact1 |
| Current smoking |
|
Yes |
| Past smoking |
|
Yes |
| Alcohol use |
|
No |
| Physical activity |
Yes |
No |
| Nutrition (yes/no) |
Yes |
No |
| - Number of food items available (approximately) |
<20 only food group level |
|
| - Method(s) of dietary assessment (e.g. 24h-recall, food frequency questionnaire, dietary records) |
FFQ
|
|
| - Supplement use |
Yes
|
Yes |
| Anthropometry |
Baseline |
Recontact1 |
| Weight and height |
|
Yes |
| - Measured or self-reported |
|
Measured |
| Unintended weight loss |
|
No |
| Waist circumference |
|
Yes |
| - Measured or self-reported |
|
Measured |
| Hip circumference |
|
Yes |
| Measured or self-reported |
|
Measured |
| Blood pressure |
Baseline |
Recontact1 |
| Measured blood pressure |
|
Yes |
| History of hypertension |
|
Yes |
| Blood tests |
Baseline |
Recontact1 |
| Total cholesterol |
|
Yes |
| HDL cholesterol |
|
Yes |
| Triglycerides |
|
Yes |
| - Fasting period |
|
? |
| ApoA1 |
|
No |
| ApoB |
|
No |
| Glucose |
Yes
|
No |
| - Fasting period |
|
|
| Glucose tolerance test |
|
No |
| HbA1c |
|
No |
| GGT |
Yes |
No |
| CRP |
|
No |
| 25-Hydroxy-Vitamin D |
Yes
|
No |
| Other tests (specify) |
Others available on request
|
No |
| Availability of frozen sera for further analysis |
Possible
|
Possible |
| - Storage temperature (°C) of sera |
|
|
| Availability of frozen plasma for further analysis |
Possible |
Possible |
| - Storage temperature (°C) of plasma |
|
|
| Genetics |
Baseline |
Recontact1 |
| Genotypic data |
Yes
|
Yes |
| GWAS (specify) |
|
|
| Other high-throughput array data (specify) |
|
|
| Availability of DNA for further genotyping |
|
|
| Plated DNA |
|
|
| Otherwise stored DNA |
|
|
| Other measurements |
Baseline |
Recontact1 |
| Perceived health |
|
No |
| Cognitive decline/dementia |
|
Yes - MMSE
|
| Depression |
|
Yes |
| Grip Strength |
|
No |
| Lung function |
|
Yes
|
| Audiometry |
|
No |
| Measurement of bone density (DEXA) |
|
No |
| Quality of life instruments (such as SF-12, EUROQoL) |
|
No |
| Limitations in ADL/IADL (i.e. Activities of daily living/Instrumental activities of daily living) |
|
No |
| Multimorbidity instruments (such as CIRS-G) |
|
No |
| Frailty scales |
|
No |
| Reproductive history (for women) |
|
N/A |
| Menstruation and menopausal status |
|
N/A |
| Fertility problems |
|
N/A |
| Pregnancies |
|
N/A |
| Breast feeding |
|
N/A |
| Hysterectomy and ovariectomy |
|
N/A |
| History of oral contraceptive use |
|
N/A |
| History of menopausal hormones use |
|
N/A |
| Current use of exogenous hormones |
|
N/A |
| Use of drugs |
Yes |
Yes |
| Availability of classification of drugs, specify (e.g. Anatomical Therapeutic Chemical(ATC) classification system) |
No |
No |
| Additional Topics |
Baseline |
Recontact1 |
| |
Attitude Survey
|
Social support questions
Dental questionnaire
|
Future recontacts
Other follow-up
New follow-up currently ongoing (started Autumn 2014)
Follow-up period
In year 2012 the follow-up was extended to 18yrs from baseline for each person for fatal and nonfatal events
Sources of data
- Person himself
- Relatives
- GP, specialist or occupational medicine department
- Registrar's General's data: The responsibilities of the General Registrar's Office, lead by the Registrar General, includes the administration of registration of deaths through the 26 District Registration Offices of Northern Ireland. Death certificates of deaths in Northern Ireland were obtained from the General Register Office
- Business Services Organisation (BSO)
Follow-up procedure
BSO informed the PRIME Belfast co-ordinators when any of the PRIME subjects died, moved to a health authority in Great Britain or moved outside Northern Ireland.
Each year, on the anniversary of the initial examination, each subject was followed-up by means of a questionnaire sent to his home. Some of the answers to this questionnaire lead to further enquiry.
The procedure for contacting the subjects was:
- Mail an Annual Follow-up Questionnaire, the letter of introduction and a stamped pre-addressed envelope, on the anniversary of the initial PRIME examination.
- If there is no answer try to make contact by telephone.
- If all this fails, contact:
- his doctor(s) (general practitioner and/or specialist)
- his Occupational Medicine Department
- If this is unsuccessful make a home visit and, if necessary, talk to neighbours.
- If no answer is obtained, search the Registrar General's data to verify that he is still alive.
- If the person is alive, classify him as "lost to follow-up".
- After 10 years try to establish if the subject is alive or dead by:
- searching the Registrar General's data
- reviewing the BSO reports
Whenever there was suspicion of an event, clinical information was sought directly from the hospital or general practitioner notes. All details of electrocardiograms, hospital admissions, enzymes, surgical operations, angioplasty, treatment etc. were collected. Death certificates were checked for supporting clinical and post-mortem information on cause of death. Whenever necessary, the circumstances of death were obtained from the practitioner or the family.
End-points covered through the follow-up
- All deaths:Yes
- Specification of the cause: Yes
- Non-fatal acute coronary events: Yes
- Cognitive impairment/dementia: No
- Nursing home admission: No
ICD-version used for classification of diseases in the data
see MORGAM
References
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