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This page last changed on 30.01.2015 by kkuk.
Link to EPIC Elderly cohort description
Contact persons for the cohort description
Prof Petra H Peeters, MD, PhD
Partner
Institute
Dept Epidemiology, Julius center, University Medical Center Utrecht, the Netherlands
Key personnel for CHANCES
Responsible person: Prof Petra H. Peeters
Other Key personnel: Prof Yvonne T. van der Schouw
Definition of the cohort
EPIC Utrecht (OR Prospect-EPIC; One of the two cohorts in EPICnl)
Target population
Women participating in population based breast screening, Utrecht, Netherlands
Recruitment
Invitation by letter
Years of recruitment
1993-97
Size of the cohort
17,537 total, age 49-70 years
Recontacts
Yes
Period
3-5 years after baseline
Approach
By letter
Measurements at baseline and recontacts
| Socioeconomic |
Baseline |
Recontact 1
|
| Education |
x |
|
| Income |
- |
|
| Marital status |
x |
|
| Occupation |
- |
|
| Employment status |
x |
|
| History of |
Baseline |
Recontact 1 |
| Diabetes |
x |
|
| Dyslipidemia |
|
|
| Coronary heart disease |
x |
|
| Stroke |
x |
|
| Cancer |
x |
|
| Benign neoplasms |
- |
|
| Fracture |
x |
|
| - Which site(s)? |
Hip, wrist, vertebra |
|
| Osteoporosis |
|
|
| Family history of |
Baseline |
Recontact 1 |
| Coronary heart disease |
- |
|
| Stroke |
- |
|
| Diabetes |
- |
|
| Cancer |
Only breast |
|
| Lifestyle |
Baseline |
Recontact 1 |
| Current smoking |
x |
|
| Past smoking |
x |
|
| Alcohol use |
x |
|
| Physical activity |
x |
|
| Nutrition (yes/no) |
x |
|
| - Number of food items available (approximately) |
|
|
| - Method(s) of dietary assessment (e.g. 24h-recall, food frequency questionnaire, dietary records) |
FFQ, 8% sample 24h-recall |
|
| - Supplement use |
x |
|
| Anthropometry |
Baseline |
Recontact 1 |
| Weight and height |
x |
|
| - Measured or self-reported |
measured |
|
| Unintended weight loss |
- |
|
| Waist circumference |
x |
|
| - Measured or self-reported |
measured |
|
| Hip circumference |
x |
|
| Measured or self-reported |
measured |
|
| Blood pressure |
Baseline |
Recontact 1 |
| Measured blood pressure |
x |
|
| History of hypertension |
x |
|
| Blood tests |
Baseline |
Recontact 1 |
| Total cholesterol |
- |
|
| HDL cholesterol |
- |
|
| Triglycerides |
- |
|
| - Fasting period |
- |
|
| ApoA1 |
- |
|
| ApoB |
- |
|
| Glucose |
- |
|
| - Fasting period |
- |
|
| Glucose tolerance test |
- |
|
| HbA1c |
- |
|
| GGT |
- |
|
| CRP |
- |
|
| 25-Hydroxy-Vitamin D |
- |
|
| Other tests (specify) |
- |
|
| Availability of frozen sera for further analysis |
x |
|
- Storage temperature (°C) of sera
|
Liquid nitrogen |
|
| Availability of frozen plasma for further analysis |
x |
|
- Storage temperature (°C) of plasma
|
Liquid nitrogen |
|
| Genetics |
Baseline |
Recontact 1 |
| Genotypic data |
- |
|
| GWAS (specify) |
- |
|
| Other high-throughput array data (specify) |
- |
|
| Availability of DNA for further genotyping |
- |
|
| Plated DNA |
- |
|
| Otherwise stored DNA |
- |
|
| Other measurements |
Baseline |
Recontact 1 |
| Perceived health |
- |
|
| Cognitive decline/dementia |
- |
|
| Depression |
- |
|
| Grip Strength |
- |
|
| Lung function |
- |
|
| Audiometry |
- |
|
| Measurement of bone density (DEXA) |
- |
|
| Quality of life instruments (such as SF-12, EUROQoL) |
- |
|
| Limitations in ADL/IADL (i.e. Activities of daily living/Instrumental activities of daily living) |
- |
|
| Multimorbidity instruments (such as CIRS-G) |
- |
|
| Frailty scales |
- |
|
| Reproductive history (for women) |
x |
|
| Menstruation and menopausal status |
x |
|
| Fertility problems |
x |
|
| Pregnancies |
x |
|
| Breast feeding |
x |
|
| Hysterectomy and ovariectomy |
x |
|
| History of oral contraceptive use |
x |
|
| History of menopausal hormones use |
x |
|
| Current use of exogenous hormones |
x |
|
| Use of drugs |
- |
|
| Availability of classification of drugs, specify (e.g. Anatomical Therapeutic Chemical(ATC) classification system) |
- |
|
| Additional Topics |
Baseline |
Recontact 1 |
| |
|
|
| |
|
|
Future recontacts
Planned, only by questionnaire
Other follow-up
Follow-up period
Until 2010 (updated every 2-3 years)
Sources of data
Cancer Registry, Hospital Discharge diagnosis, Municipality Registry
Follow-up procedure
Linkage to registries
End-points covered through the follow-up
- All deaths: yes
- Specification of the cause: yes
- Non-fatal cancers: yes
- Cancer survival: (combining with all deaths: yes)
- Non-fatal acute coronary events: yes (hospitalized)
- Non-fatal stroke: yes (hospitalized)
- Cognitive impairment/dementia: no
- Nursing home admission: no
ICD-version used for classification of diseases in the data
- Which version was used (if several, specify years and/or data sources for each):
References
1: Boker LK, van Noord PA, van der Schouw YT, Koot NV, Bueno de Mesquita HB, Riboli E, Grobbee DE, Peeters PH. Prospect-EPIC Utrecht: study design and characteristics of the cohort population. European Prospective Investigation into Cancer and Nutrition. Eur J Epidemiol. 2001;17(11):1047-53. PubMed PMID: 12380720.
2: Beulens JW, Monninkhof EM, Verschuren WM, van der Schouw YT, Smit J, Ocke MC, Jansen EH, van Dieren S, Grobbee DE, Peeters PH, Bueno-de-Mesquita HB. Cohort profile: the EPIC-NL study. Int J Epidemiol. 2010 Oct;39(5):1170-8. doi: 10.1093/ije/dyp217. Epub 2009 May 29. PubMed PMID: 19483199.
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